Document 0754
 DOCN  M9490754
 TI    A 12-month study of the effects of oral zidovudine on neurodevelopmental
       functioning in a cohort of vertically HIV-infected inner-city children.
 DT    9411
 AU    Nozyce M; Hoberman M; Arpadi S; Wiznia A; Lambert G; Dobroszycki J;
       Chang CJ; St Louis Y; Department of Pediatrics, Bronx-Lebanon Hospital
       Center, NY; 10457.
 SO    AIDS. 1994 May;8(5):635-9. Unique Identifier : AIDSLINE MED/94338599
 AB    OBJECTIVE: To examine the effects of oral zidovudine on the
       neurodevelopmental functioning of HIV-infected children. METHODS: Oral
       zidovudine was administered to 54 symptomatic children with vertically
       transmitted HIV infection (Centers for Disease Control and Prevention
       class P2). All children were recruited from an inner-city pediatric
       HIV/AIDS outpatient clinic and ranged in age from 2 months to 12 years
       and 11 months (mean age, 3 years) at entry. Neurodevelopmental
       functioning, height and weight, and lymphocyte subpopulation data were
       ascertained for all the children pretherapy, and 6 and 12 months
       post-therapy initiation. RESULTS: Analysis of the 6- and 12-month
       post-initiation drug data found no significant change in
       neurodevelopmental functioning. Height and weight percentiles remained
       the same or improved in the majority of children. CD4+ cell counts
       declined over the treatment period with CD4+ counts < 500 x 10(6)/l
       observed in 15% of the children pre-therapy, and 33% after 1 year.
       CONCLUSION: In contrast with previously published data, the present
       study observed no improvement in neurodevelopmental functioning in
       HIV-infected children treated with oral zidovudine.
 DE    Blacks  Body Height  Body Weight  Child  Child Development
       Disorders/ETIOLOGY/*PREVENTION & CONTROL  Child, Preschool  Cognition
       Disorders/ETIOLOGY/PREVENTION & CONTROL  Cohort Studies  Female
       Hispanic Americans  Human  HIV Infections/CONGENITAL/COMPLICATIONS/*DRUG
       THERAPY/  EPIDEMIOLOGY  Infant  Leukocyte Count  Male
       Neuropsychological Tests  New York City/EPIDEMIOLOGY  Poverty
       Psychomotor Disorders/ETIOLOGY/PREVENTION & CONTROL  Socioeconomic
       Factors  Treatment Outcome  T4 Lymphocytes  Urban Population
       Zidovudine/ADVERSE EFFECTS/*THERAPEUTIC USE  CLINICAL TRIAL  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).