Document 0012
 DOCN  M94A0012
 TI    [The specific activity and immunological safety of the intranasal method
       of revaccination with a live measles vaccine made from the Leningrad-16
       strain]
 DT    9412
 AU    Iuminova NV; Krasnova VP; Liashenko VA; Vedunova SL
 SO    Vopr Virusol. 1993 May-Jun;38(3):111-3. Unique Identifier : AIDSLINE
       MED/94353760
 AB    The search for alternative routes for administration of live measles
       vaccine is associated both with the threat of infection with human
       immunodeficiency virus, hepatitis B virus, and with the development of a
       more physiological, natural and less traumatic mode of vaccine
       administration. The influence of the intranasal administration on the
       general condition of the immune system, its immunomodulating effect (the
       emergence of inducer suppressors, cell response to the inactivated
       virus), was studied as well as the level and intensity of secretory and
       general humoral immunity. The studies confirmed the immunological
       effectiveness and safety of the intranasal administration of a live
       measles vaccine and suggested its advantages for revaccination against
       measles.
 DE    Administration, Intranasal  Adolescence  Adult  Antibodies, Viral/BLOOD
       Antibody Specificity  Antigenic Determinants/IMMUNOLOGY  Antigens,
       Viral/IMMUNOLOGY  Comparative Study  Dose-Response Relationship,
       Immunologic  English Abstract  Human  IgA/BLOOD  IgG/BLOOD
       Immunization, Secondary/ADVERSE EFFECTS/*METHODS  Measles
       Vaccine/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/  *IMMUNOLOGY  Measles
       Virus/IMMUNOLOGY  Safety  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).