Document 0066
 DOCN  M94A0066
 TI    Synthesis and antiviral activity evaluation of some aminoadamantane
       derivatives.
 DT    9412
 AU    Kolocouris N; Foscolos GB; Kolocouris A; Marakos P; Pouli N; Fytas G;
       Ikeda S; De Clercq E; Department of Pharmacy, University of Athens,
       Greece.
 SO    J Med Chem. 1994 Sep 2;37(18):2896-902. Unique Identifier : AIDSLINE
       MED/94351651
 AB    The synthesis of some spiro[cyclopropane-1,2'-adamantan]-2-amines and
       methanamines and some spiro[pyrrolidine-2,2'-adamantanes] is described.
       The title compounds were evaluated against a wide range of viruses
       (influenza A, influenza B, parainfluenza 3, RSV, HSV-1, TK- HSV-1,
       HSV-2, vaccinia, vesicular stomatitis, polio 1, coxsackie B4, sindbis,
       semliki forest, Reo 1, HIV-1, and HIV-2), and some of them (compounds
       6b, 6c, 9a, 16a, 16b, and 17) inhibited the cytopathicity of influenza A
       virus at a concentration significantly lower than that of amantadine and
       also significantly lower than the concentrations at which they proved
       cytotoxic to the host cells. None of the new aminoadamantane derivatives
       was active against influenza B virus or any of the other viruses tested,
       which points to their specificity as anti-influenza A virus agents.
 DE    Adamantane/*ANALOGS & DERIVATIVES/CHEMICAL SYNTHESIS/PHARMACOLOGY
       Animal  Antiviral Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Cell
       Division/DRUG EFFECTS  Cell Line  Cell Survival/DRUG EFFECTS
       Cercopithecus aethiops  Cytopathogenic Effect, Viral/DRUG EFFECTS  Dogs
       Human  Spiro Compounds/CHEMICAL SYNTHESIS/PHARMACOLOGY  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).