Document 0073
 DOCN  M94A0073
 TI    Activity of antimicrobial drugs evaluated by agar dilution and
       radiometric methods against strains of Nocardia asteroides isolated in
       Italy from immunocompromised patients.
 DT    9412
 AU    Scopetti F; Iona E; Fattorini L; Goglio A; Franceschini N; Amicosante G;
       Orefici G; laboratorio di Batteriologia e Micologia Medica, Istituto;
       Superiore di Sanita, Rome, Italy.
 SO    J Chemother. 1994 Feb;6(1):29-34. Unique Identifier : AIDSLINE
       MED/94351347
 AB    Benzylpenicillin, amoxicillin, amoxicillin plus clavulanic acid,
       cephalothin, cephaloridine, cefotaxime, imipenem, erythromycin,
       clarithromycin, azithromycin, amikacin, ciprofloxacin and
       trimethoprim-sulfamethoxazole were tested in vitro by the agar dilution
       method against eleven strains of Nocardia asteroides isolated both from
       AIDS and other immunocompromised patients. Imipenem, amikacin and
       trimethoprim-sulfamethoxazole were shown to be the most active drugs
       with minimum inhibitory concentrations (MIC) values nearly always lower
       than concentrations achievable in blood. Ciprofloxacin, cephaloridine
       and cefotaxime were moderately active, while the remaining drugs were
       totally ineffective. When susceptibility was assessed by the radiometric
       method the MIC90 values were uniformly lower than those in the agar
       method, possibly due to lower inactivation of drugs during incubation.
       The two methods showed a good correlation only for imipenem, amikacin
       and ciprofloxacin. The results obtained by the radiometric method seem
       to indicate that, as for mycobacteria, this method may also give a more
       accurate evaluation of the antimicrobial susceptibility of Nocardiae.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/MICROBIOLOGY
       Antibiotics/*PHARMACOLOGY  Carbon Dioxide/ANALYSIS/METABOLISM  Carbon
       Radioisotopes  Comparative Study  Human  *Immunocompromised Host
       Microbial Sensitivity Tests  Nocardia asteroides/*DRUG
       EFFECTS/METABOLISM  Nocardia Infections/*IMMUNOLOGY/*MICROBIOLOGY
       Radiometry  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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