Document 0084
 DOCN  M94A0084
 TI    The mniopetals, new inhibitors of reverse transcriptases from a
       Mniopetalum species (Basidiomycetes). I. Producing organism,
       fermentation, isolation and biological activities.
 DT    9412
 AU    Kuschel A; Anke T; Velten R; Klostermeyer D; Steglich W; Konig B; LB
       Biotechnology, The University, Kaiserslautern, FRG.
 SO    J Antibiot (Tokyo). 1994 Jul;47(7):733-9. Unique Identifier : AIDSLINE
       MED/94350715
 AB    Six novel enzyme inhibitors of RNA-directed DNA-polymerases of human
       immunodeficiency-, avian myeloblastosis and murine leukemia viruses were
       isolated from fermentations of a canadian Mniopetalum species. They were
       named mniopetals A, B, C, D, E and F. Their structures were elucidated
       by spectroscopic methods. The compounds, in addition to their inhibitory
       activities on reverse transcriptases, exhibit antimicrobial and
       cytotoxic properties.
 DE    Antibiotics, Antifungal/*BIOSYNTHESIS/ISOLATION & PURIF/  *PHARMACOLOGY
       Antiviral Agents/*CHEMICAL SYNTHESIS/ISOLATION & PURIF/  *PHARMACOLOGY
       Basidiomycetes/*CHEMISTRY/*METABOLISM  Fermentation  HIV-1/ENZYMOLOGY
       Moloney Leukemia Virus/ENZYMOLOGY  Myeloblastosis Virus,
       Avian/ENZYMOLOGY  Reverse Transcriptase/*ANTAGONISTS & INHIB  Support,
       Non-U.S. Gov't  Viral Proteins/ANTAGONISTS & INHIB  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).