Document 0089
 DOCN  M94A0089
 TI    Clinical significance of positive direct antiglobulin test in patients
       with HIV infection.
 DT    9412
 AU    De Angelis V; Biasinutto C; Pradella P; Vaccher E; Spina M; Tirelli U;
       Servizio Immunotrasfusionale e Analisi Cliniche, I.R.C.C.S.; Centro di
       Riferimento Oncologico, Aviano, Italy.
 SO    Infection. 1994 Mar-Apr;22(2):92-5. Unique Identifier : AIDSLINE
       MED/94350513
 AB    A direct antiglobulin test (DAT) was performed in 70 patients with
       anti-HIV antibodies (group A: seropositive patients without or with
       minimal disease and group B: AIDS patients with or without
       malignancies). A positive DAT was found in 24 of 70 patients (34%,
       significantly higher compared to 0.1% in healthy controls) and a higher
       prevalence of positive DAT was observed in group B than in group A
       patients (55% versus 21% p < 0.01). When comparing DAT-positive and
       negative patients within the same clinical group, no significant
       difference is seen in haemoglobin levels. There is no difference in
       serum bilirubin, haptoglobin or reticulocyte count between DAT-positive
       and negative patients altogether or in the same clinical group. AZT
       therapy seems to exert no significant influence on the onset of a
       positive DAT. The results confirm a high prevalence of positive DAT in
       patients with HIV antibodies, mainly in worse clinical conditions, and
       suggest that a positive DAT might be a prognostic factor in the clinical
       course of the disease.
 DE    Adult  Anemia, Hemolytic/*BLOOD/EPIDEMIOLOGY/*ETIOLOGY  Bilirubin/BLOOD
       Case-Control Studies  *Coombs' Test  CD4-CD8 Ratio  Female
       Haptoglobins/ANALYSIS  Hematocrit  Hemoglobins/ANALYSIS  Human  HIV
       Antibodies/BLOOD  HIV Infections/CLASSIFICATION/*COMPLICATIONS  Male
       Middle Age  Prevalence  Prognosis  Reticulocyte Count  Risk Factors
       Severity of Illness Index  JOURNAL ARTICLE

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