Document 0122
 DOCN  M94A0122
 TI    Phenotypes of lymphocytes infiltrating non-small cell lung cancer
       tissues and its variation with histological types of cancer.
 DT    9412
 AU    Yoshino I; Yano T; Murata M; Miyamoto M; Ishida T; Sugimachi K; Kimura
       G; Nomoto K; Department of Virology, Kyushu University, Japan.
 SO    Lung Cancer. 1993 Oct;10(1-2):13-9. Unique Identifier : AIDSLINE
       MED/94348838
 AB    We investigated surface markers of lymphocytes infiltrating four
       different histological non-small cell lung cancer tissues obtained at
       surgery and the corresponding peripheral blood lymphocytes (PBL) of 40
       clinical cases, who had undergone no prior anti-cancer treatment, by
       flowcytometry. In estimation of the mean proportion of each lymphocyte
       subset, a paired Wilcoxon test revealed that tumor-infiltrating
       lymphocytes (TIL) exhibited significantly higher values of CD3+ cells (P
       < 0.05), CD8+ cells (P < 0.05) and CD20+ cells (P < 0.01), and lower
       value of CD16+cells (P < 0.05), as compared with those in PBL. The
       Spearman test revealed that none of the values of surface markers in TIL
       statistically correlated with those in the corresponding PBL (r < 0.6, P
       > 0.05). Although there was no significant difference between the mean
       CD4/CD8 ratio of total TIL and that of PBL, TIL of 12 patients with
       squamous cell carcinoma almost always showed lower values of CD4/CD8
       ratio than those in PBL (P < 0.05), while the CD4/CD8 ratio was similar
       between TIL and PBL in adenocarcinoma. These results suggest that TIL of
       lung cancers represent specific immunological responses, whose
       characteristic depend on the histological types of lung cancers.
 DE    Carcinoma, Non-Small-Cell Lung/*IMMUNOLOGY  CD4-CD8 Ratio  Human
       Immunophenotyping  Lung Neoplasms/*IMMUNOLOGY  Lymphocytes,
       Tumor-Infiltrating/*IMMUNOLOGY  T-Lymphocyte Subsets/IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).