Document 0130
 DOCN  M94A0130
 TI    EBER gene expression in Epstein-Barr virus-associated hematopoietic
       neoplasms.
 DT    9412
 AU    Randhawa PS; Demetris J; Nalesnik MA; Department of Pathology,
       Presbyterian University Hospital,; Pittsburgh, Pennsylvania 15213.
 SO    Leuk Lymphoma. 1994 May;13(5-6):387-92. Unique Identifier : AIDSLINE
       MED/94348376
 AB    Epstein-Barr virus encoded RNA's (EBER) are small RNA species found in
       cells latently infected by the virus. The physiological function of
       these molecules is currently a matter of speculation. Nonetheless, their
       presence in extremely high copy number has made it possible to reliably
       detect the Epstein-Barr virus by in-situ hybridization, in human tissues
       routinely fixed with formalin and embedded in paraffin. Such studies
       have enhanced our understanding of a number of hematologic malignancies,
       particularly Hodgkin's disease, angiocentric immunoproliferative lesions
       and angio-immunoblastic lymphadenopathy. In addition, sequential EBER
       in-situ hybridization studies on lymphoid tissues should enable
       oncologists to monitor the development of lymphoproliferative disorders
       occurring in the setting of organ transplantation, AIDS and hereditary
       immunodeficiencies.
 DE    Hematologic Diseases/*GENETICS/*MICROBIOLOGY  Herpesviridae
       Infections/*GENETICS/*MICROBIOLOGY  Herpesvirus 4, Human/*GENETICS
       Human  Neoplasms/*GENETICS/*MICROBIOLOGY  RNA-Binding Proteins/*GENETICS
       Tumor Virus Infections/*GENETICS/*MICROBIOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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