Document 0163
 DOCN  M94A0163
 TI    Impaired parathyroid hormone release in human immunodeficiency virus
       infection.
 DT    9412
 AU    Hellman P; Albert J; Gidlund M; Klareskog L; Rastad J; Akerstrom G;
       Juhlin C; Department of Surgery, University Hospital, Uppsala, Sweden.
 SO    AIDS Res Hum Retroviruses. 1994 Apr;10(4):391-4. Unique Identifier :
       AIDSLINE MED/94347463
 AB    Patients with human immunodeficiency virus type 1 (HIV-1) seropositivity
       exhibited significantly lower intact serum parathyroid hormone (PTH)
       values (mean, 13.6 ng/liter; n = 44) than healthy controls (mean, 38.1
       ng/liter; p < 0.001; n = 50). The reduction was greater among patients
       with no or mild immunodeficiency (> 400 x 10(6) CD4+ lymphocytes/ml
       blood; n = 22) than in those with severe immunodeficiency (< 200 x 10(6)
       CD4+ lymphocytes/ml blood; n 22; p = 0.03), although total serum calcium
       was normal in all groups. Patients with severe immunodeficiency
       demonstrated an inverse correlation between total serum calcium and
       serum PTH (r2 = 0.367; p < 0.01), which was also present in healthy
       controls (r2 = 0.482; p < 0.001), but not among the seropositive
       patients with no or mild immunodeficiency (r2 = 0.017; p = 0.58).
       Parathyroid cells express a protein recognized by antibodies directed
       against CD4, the HIV-1 receptor. This implies that these cells may be
       directly infected with HIV-1 and also interact with circulating
       autoantibodies against CD4, thus resulting in impaired PTH release.
 DE    Antigens, CD4/IMMUNOLOGY  Autoantibodies/BLOOD  Calcium/BLOOD  Female
       Human  HIV Infections/*BLOOD/IMMUNOLOGY  *HIV-1  Leukocyte Count  Male
       Parathyroid Glands/IMMUNOLOGY  Parathyroid
       Hormones/BLOOD/*DEFICIENCY/SECRETION  Support, Non-U.S. Gov't  T4
       Lymphocytes  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).