Document 0174
 DOCN  M94A0174
 TI    Effect of serum from HIV-infected subjects on superoxide production by
       polymorphonuclear neutrophils.
 DT    9412
 AU    Pieri E; Orsilles MA; Laboratorio de Immunologia, Hospital Rawson,
       Cordoba,; Argentina.
 SO    APMIS. 1994 Jun;102(6):427-31. Unique Identifier : AIDSLINE MED/94347331
 AB    Superoxide (O2.-) production by polymorphonuclear neutrophils (PMN) was
       assessed in 17 subjects with asymptomatic infection (AI), 16 patients
       with acquired immunodeficiency syndrome (AIDS), and 12 healthy normal
       subjects. The effect of patients' serum on the oxidative activity of
       normal and patients' PMN was also investigated. The O2.- production,
       nonstimulated and stimulated with zymosan particles in the presence of
       normal serum, was similar to that of normal controls in both groups of
       patients. The serum from 11 out of the 17 AI subjects (65%) induced an
       increase in the stimulated O2.- production in normal and patients' PMN,
       while the serum from 8 out of the 16 AIDS patients (50%) induced a
       diminution. These effects did not appear to be related to complement C3
       and circulating immune complex levels, but suggest that PMN of
       HIV-seropositive patients do not present an intrinsic dysfunction and
       that the impact of serum factor(s) affects the normal oxidative activity
       of these cells depending on the stage of infection.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD  Adult  Blood
       Proteins/*PHARMACOLOGY  Comparative Study  Complement 3/ANALYSIS  Female
       Human  Male  Middle Age  Neutrophils/DRUG EFFECTS/*METABOLISM
       Phagocytes/DRUG EFFECTS/METABOLISM  Superoxides/*METABOLISM  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).