Document 0175
 DOCN  M94A0175
 TI    T-cell-mediated immunopathology versus direct cytolysis by virus:
       implications for HIV and AIDS.
 DT    9412
 AU    Zinkernagel RM; Hengartner H; Institute of Experimental Immunology,
       University of Zurich,; Switzerland.
 SO    Immunol Today. 1994 Jun;15(6):262-8. Unique Identifier : AIDSLINE
       MED/94347174
 AB    It has been much debated as to whether CD4+ T-cell depletion and the
       pathogenesis of AIDS is the result of direct cytolytic effects of human
       immunodeficiency virus (HIV), T-cell apoptosis by nonspecific
       activation, dysregulation of cytokine production, or autoimmunity. In
       this context, Rolf Zinkernagel and Hans Hengartner discuss data from
       model infections with non-cytopathic viruses. They suggest that HIV may
       cause immunosuppression, not by direct cytolytic effects, but rather by
       a conventional virus-specific cytotoxic T-cell-mediated immunopathology.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Apoptosis/IMMUNOLOGY
       Autoimmunity  Human  HIV/*IMMUNOLOGY  HIV Infections/*IMMUNOLOGY
       Lymphocyte Depletion  Support, Non-U.S. Gov't  T-Lymphocytes,
       Cytotoxic/IMMUNOLOGY  T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY  T4
       Lymphocytes/*IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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