Document 0188
 DOCN  M94A0188
 TI    HIV: virology and mechanisms of disease.
 DT    9412
 AU    King SR; Department of Immunology and Microbiology, Wayne State
       University; School of Medicine, Detroit, Michigan.
 SO    Ann Emerg Med. 1994 Sep;24(3):443-9. Unique Identifier : AIDSLINE
       MED/94361314
 AB    HIV is the etiologic agent of AIDS. AIDS results from the loss of cells
       that are central to immune responses, T lymphocytes that express the CD4
       protein on their surface. This paper relates HIV structure and
       replication to the clinical course of HIV infection. The virology of HIV
       replication is discussed first at the cellular and molecular levels. The
       course of HIV infection in vivo then is discussed and related to HIV
       replication. Finally, models that have been proposed to explain the
       mechanism whereby HIV causes immunodeficiency are considered. Although
       much is known about the growth of the virus both in vitro and in vivo,
       many questions remain about how HIV can deplete CD4-positive T
       lymphocytes and cause AIDS.
 DE    Human  HIV/CHEMISTRY/*PHYSIOLOGY/*PATHOGENICITY  HIV
       Infections/BLOOD/*IMMUNOLOGY/*MICROBIOLOGY/PHYSIOPATHOLOGY
       Transcription, Genetic  Translation, Genetic  T4 Lymphocytes/IMMUNOLOGY
       Virus Replication  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).