Document 0197
 DOCN  M94A0197
 TI    Actinomyces infection of a cytomegalovirus esophageal ulcer in two
       patients with acquired immunodeficiency syndrome.
 DT    9412
 AU    Poles MA; McMeeking AA; Scholes JV; Dieterich DT; New York University
       Medical Center, NY.
 SO    Am J Gastroenterol. 1994 Sep;89(9):1569-72. Unique Identifier : AIDSLINE
       MED/94361089
 AB    Esophageal disease is a significant cause of morbidity among patients
       with the acquired immunodeficiency syndrome (AIDS). Many organisms have
       been implicated in the pathogenesis of dysphagia and odynophagia. We
       describe a unique presentation of actinomyces esophageal infection in
       two homosexual male patients with AIDS and biopsy proven CMV
       esophagitis. After failure of esophagitis to resolve with ganciclovir or
       foscarnet therapy, the patients underwent repeat endoscopy and were
       subsequently found to have a secondary infection of the ulcers by
       Actinomyces. Treatment with intravenous penicillin G resulted in
       symptomatic and histopathological resolution of esophageal disease. This
       appears to be the first report of Actinomyces infection of esophageal
       ulcers in AIDS patients, possibly a commonly overlooked diagnosis.
 DE    Actinomycosis/*DIAGNOSIS/DRUG THERAPY  Adult  AIDS-Related Opportunistic
       Infections/DIAGNOSIS/DRUG THERAPY/  *MICROBIOLOGY  Case Report
       Cytomegalovirus Infections/*DIAGNOSIS/DRUG THERAPY  Esophageal Cyst/DRUG
       THERAPY/*MICROBIOLOGY  Esophagitis/DRUG THERAPY/MICROBIOLOGY
       Foscarnet/THERAPEUTIC USE  Ganciclovir/THERAPEUTIC USE  Human  Male
       Penicillin G/THERAPEUTIC USE  JOURNAL ARTICLE

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