Document 0207
 DOCN  M94A0207
 TI    Reduced rate of disease development after HIV-2 infection as compared to
       HIV-1.
 DT    9412
 AU    Marlink R; Kanki P; Thior I; Travers K; Eisen G; Siby T; Traore I; Hsieh
       CC; Dia MC; Gueye EH; et al; Department of Cancer Biology, Harvard
       School of Public Health,; Boston, MA 02115.
 SO    Science. 1994 Sep 9;265(5178):1587-90. Unique Identifier : AIDSLINE
       MED/94360247
 AB    Human immunodeficiency virus type-2 (HIV-2) is a close relative of the
       prototype acquired immunodeficiency syndrome (AIDS) virus, HIV-1. HIV-2
       is biologically similar to HIV-1, but information is lacking concerning
       clinical outcomes of HIV-2-infected individuals. From 1985 to 1993, a
       prospective clinical study was conducted in women with HIV-2 and HIV-1
       infection to determine and compare rates of disease development.
       HIV-1-infected women had a 67% probability of AIDS-free survival 5 years
       after seroconversion in contrast with 100% for HIV-2-infected women. In
       addition to having significantly less HIV-related disease outcome in
       HIV-2 enrollees compared to HIV-1 enrollees, the rate of developing
       abnormal CD4+ lymphocyte counts with HIV-2 infection was also
       significantly reduced. This natural history study demonstrates that
       HIV-2 has a reduced virulence compared to HIV-1.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/IMMUNOLOGY/
       *MICROBIOLOGY  Adult  Cohort Studies  Comparative Study  Female  Human
       HIV Infections/EPIDEMIOLOGY/IMMUNOLOGY/*MICROBIOLOGY
       HIV-1/*PATHOGENICITY  HIV-2/*PATHOGENICITY  Immune Tolerance  Incidence
       Leukocyte Count  Prospective Studies  Senegal/EPIDEMIOLOGY  Support,
       U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  T4 Lymphocytes
       Virulence  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).