Document 0247
 DOCN  M94A0247
 TI    CD3-dependent lymphocyte activation by human T cell leukaemia virus type
       I-producing T cells.
 DT    9412
 AU    Kimata JT; Wong FH; Ratner L; Department of Medicine, Washington
       University School of Medicine,; St Louis, Missouri 63110.
 SO    J Gen Virol. 1994 Sep;75 ( Pt 9):2433-7. Unique Identifier : AIDSLINE
       MED/94358746
 AB    Human T cell leukaemia virus type I-(HTLV-I) transformed cells are
       capable of stimulating the proliferation of normal T lymphocytes, or
       stimulating interleukin 2 expression in Jurkat T lymphoid cells. This
       effect is mediated by the CD2/lymphocyte function-associated antigen 3
       (LFA-3) adhesion/signalling pathway. The current work demonstrates that
       CD3 is also required for this effect, suggesting that the T cell
       receptor (TCR)/CD3 complex is mediating this effect. However, this
       effect does not appear to be due to a superantigen since no change in
       TCR expression was found after HTLV-I-mediated proliferation, nor was
       proliferation inhibited by an antibody against the specific TCR
       expressed on Jurkat cells (TCR V beta 8).
 DE    Adult  Antigens, CD/*PHYSIOLOGY  Antigens, CD3/*PHYSIOLOGY  Antigens,
       Differentiation, T-Lymphocyte/PHYSIOLOGY  Cells, Cultured  Human  HLA-D
       Antigens/IMMUNOLOGY  HTLV-I/*IMMUNOLOGY  *Lymphocyte Transformation
       Receptors, Antigen, T-Cell, alpha-beta/IMMUNOLOGY  Receptors,
       Immunologic/PHYSIOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).