Document 0256
 DOCN  M94A0256
 TI    Deficiency in antibody response to human cytomegalovirus glycoprotein gH
       in human immunodeficiency virus-infected patients at risk for
       cytomegalovirus retinitis.
 DT    9412
 AU    Rasmussen L; Morris S; Wolitz R; Dowling A; Fessell J; Holodniy M;
       Merigan TC; Stanford University School of Medicine, Center for AIDS
       Research; and Division of Infectious Diseases and Geographic Medicine,;
       California 94305.
 SO    J Infect Dis. 1994 Sep;170(3):673-7. Unique Identifier : AIDSLINE
       MED/94358505
 AB    Human immunodeficiency virus (HIV)-infected patients at risk for
       symptomatic human cytomegalovirus (CMV) infection were studied for serum
       antibody to CMV glycoproteins gH and gB. Antibody titers to gB in
       HIV-seropositive patients, irrespective of CD4 cell counts or presence
       of CMV retinitis, were significantly higher than titers in
       HIV-seronegative, CMV-seropositive patients but were comparable to
       titers detected in HIV-seronegative patients with CMV mononucleosis. In
       contrast, antibody to gH was rarely detected in HIV-seropositive
       patients with CD4 cell counts > 100/mm3 compared with patients with
       counts > 100/mm3. The inability to detect gH antibody at a time of high
       risk for symptomatic CMV retinitis suggests that immune intervention
       with either gH-specific vaccine or passive immunotherapy may benefit
       HIV-infected persons at risk for symptomatic CMV disease.
 DE    Antibodies, Viral/*BLOOD  *Antibody Formation  AIDS-Related
       Opportunistic Infections/*EPIDEMIOLOGY  Comparative Study
       Cytomegalovirus/*IMMUNOLOGY  Cytomegalovirus Retinitis/*EPIDEMIOLOGY
       Enzyme-Linked Immunosorbent Assay  Human  *HIV Seronegativity  HIV
       Seropositivity/BLOOD/*MICROBIOLOGY  IgG/*BLOOD  Leukocyte Count
       Reference Values  Risk Factors  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  T4 Lymphocytes/IMMUNOLOGY  Viral Envelope
       Proteins/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).