Document 0258
 DOCN  M94A0258
 TI    Predictors of survival in patients with AIDS and disseminated
       Mycobacterium avium complex disease.
 DT    9412
 AU    Horsburgh CR Jr; Metchock B; Gordon SM; Havlik JA Jr; McGowan JE Jr;
       Thompson SE 3rd; Department of Medicine, Grady Memorial Hospital,
       Atlanta,; Georgia.
 SO    J Infect Dis. 1994 Sep;170(3):573-7. Unique Identifier : AIDSLINE
       MED/94358490
 AB    Patients with AIDS and disseminated Mycobacterium avium complex disease
       (DMAC), as defined by the presence of a positive blood culture for MAC,
       were studied retrospectively to define the natural history of DMAC. All
       patients had fevers, severe anemia (hematocrit < 26%), or both.
       Eighty-seven (76%) had signs, symptoms, or laboratory findings related
       to the gastrointestinal tract, but no distinct syndrome was identified.
       Sixty-nine patients received antimycobacterial therapy; assignment to
       therapy was not randomized. In a proportional hazards analysis, shorter
       survival was associated with higher initial level of mycobacteremia
       (relative risk [RR], 1.86; 95% confidence interval [CI], 1.49-2.31; P <
       .001), while administration of antimycobacterial chemotherapy (RR, 0.42;
       95% CI, 0.26-0.70; P < .001) and antiretroviral therapy (RR, 0.40; 95%
       CI, 0.22-0.73; P < .01) had protective effects. Thus, the initial level
       of mycobacteremia of patients with DMAC may have prognostic value, and
       administration of antimycobacterial and antiretroviral agents may be
       associated with prolonged survival.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY  Adult
       Antibiotics/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*MORTALITY/PHYSIOPATHOLOGY  Bacteremia/EPIDEMIOLOGY  Female
       Human  Male  Multivariate Analysis  Mycobacterium avium-intracellulare
       Infection/*MORTALITY/  PHYSIOPATHOLOGY  Predictive Value of Tests
       Prognosis  Proportional Hazards Models  Risk Factors  Survival Analysis
       Survival Rate  JOURNAL ARTICLE

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