Document 0297
 DOCN  M94A0297
 TI    Molecular characterization of murine and human OX40/OX40 ligand systems:
       identification of a human OX40 ligand as the HTLV-1-regulated protein
       gp34.
 DT    9412
 AU    Baum PR; Gayle RB 3rd; Ramsdell F; Srinivasan S; Sorensen RA; Watson ML;
       Seldin MF; Baker E; Sutherland GR; Clifford KN; et al; Department of
       Gene Expression, Immunex R&D Corporation, Seattle,; WA 98101.
 SO    EMBO J. 1994 Sep 1;13(17):3992-4001. Unique Identifier : AIDSLINE
       GENBANK/U12763
 AB    A ligand was cloned for murine OX40, a member of the TNF receptor
       family, using a T cell lymphoma cDNA library. The ligand (muOX40L) is a
       type II membrane protein with significant identity to human gp34 (gp34),
       a protein whose expression on HTLV-1-infected human leukemic T cells is
       regulated by the tax gene. The predicted structures of muOX40L and gp34
       are similar to, but more compact than, those of other ligands of the TNF
       family. Mapping of the muOX40L gene revealed tight linkage to gld, the
       FasL gene, on chromosome 1. gp34 maps to a homologous region in the
       human genome, 1q25. cDNAs for human OX40 receptor were cloned by
       cross-hybridization with muOX40, and gp34 was found to bind the
       expressed human receptor. Lymphoid expression of muOX40L was detected on
       activated T cells, with higher levels found on CD4+ rather than CD8+
       cells. The cell-bound recombinant ligands are biologically active,
       co-stimulating T cell proliferation and cytokine production. Strong
       induction of IL-4 secretion by muOX40L suggests that this ligand may
       play a role in regulating immune responses. In addition, the HTLV-1
       regulation of gp34 suggests a possible connection between virally
       induced pathogenesis and the OX40 system.
 DE    Amino Acid Sequence  Animal  Antigens, CD27/GENETICS/*METABOLISM  Base
       Sequence  Chromosome Mapping  Chromosomes, Human, Pair 1  Cloning,
       Molecular  Comparative Study  Cytokines/BIOSYNTHESIS  Female  Gene
       Expression Regulation  Human  HTLV-I/METABOLISM  Ligands  Mice  Mice,
       Inbred C57BL  Models, Molecular  Molecular Sequence Data  Receptors,
       Tumor Necrosis Factor/*GENETICS/*METABOLISM  Recombinant Fusion
       Proteins/METABOLISM  Sequence Homology, Amino Acid  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  T-Lymphocytes/METABOLISM  Tumor
       Necrosis Factor/*GENETICS/*METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).