Document 0299
 DOCN  M94A0299
 TI    Squamous-cell carcinoma of the anus in HIV-positive patients.
 DT    9412
 AU    Chadha M; Rosenblatt EA; Malamud S; Pisch J; Berson A; Department of
       Radiation Oncology, Beth Israel Medical Center, New; York, New York
       10003.
 SO    Dis Colon Rectum. 1994 Sep;37(9):861-5. Unique Identifier : AIDSLINE
       MED/94357034
 AB    PURPOSE: Patients diagnosed as having anal cancer and human
       immunodeficiency virus (HIV)-positive disease were evaluated for
       response to treatment and its associated toxicity. METHODS: We studied
       nine HIV-positive patients with squamous-cell carcinoma of the anus.
       Among them, three patients had acquired immunodeficiency syndrome
       (AIDS). The stage of disease at presentation included: one Stage 0, two
       Stage I, two Stage II, and four Stage III patients. Seven patients
       received combined modality treatment, i.e., radiation therapy and
       chemotherapy, and two patients received radiation therapy alone. The
       radiation therapy field included the pelvis and a conedown boost.
       Chemotherapy consisted of two cycles of 5-fluorouracil and mitomycin C.
       Patients have been followed from 2 to 42 (median, 8) months. RESULTS:
       Seven patients achieved a complete response clinically. All Stage I/II
       patients and one of four Stage III patients remain alive and have no
       evidence of disease. Radiation Therapy Oncology Group/European
       Organization for the Research and Treatment of Cancer Grades 3 and 4
       skin toxicity were noted in six patients, and Grades 2 and 3
       myelosuppression were noted in eight patients. The response rates
       achieved are comparable to the experience in non-HIV patients reported
       in the literature, but toxicity seems to be increased. CONCLUSION: It
       would seem reasonable to offer combined modality treatment to early
       stage, HIV-positive patients with good performance status and a history
       of minor opportunistic infections. The value of combined modality in
       AIDS patients and those who present with advanced stages of the disease
       is questionable.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Aged
       Antineoplastic Agents, Combined/*THERAPEUTIC USE  Anus
       Neoplasms/DIAGNOSIS/ETIOLOGY/MORTALITY/*RADIOTHERAPY  Carcinoma,
       Squamous Cell/DIAGNOSIS/ETIOLOGY/MORTALITY/  *RADIOTHERAPY  Combined
       Modality Therapy  Female  Fluorouracil/ADMINISTRATION & DOSAGE
       Follow-Up Studies  Human  HIV Seropositivity/*COMPLICATIONS  Male
       Middle Age  Mitomycin C/ADMINISTRATION & DOSAGE  Neoplasm Staging
       Retrospective Studies  Risk Factors  Survival Rate  Treatment Outcome
       JOURNAL ARTICLE

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