Document 0337
 DOCN  M94A0337
 TI    Viruses and Langerhans cell histiocytosis: is there a link?
 DT    9412
 AU    McClain K; Weiss RA; Baylor College of Medicine, Texas Children's
       Hospital, Houston; 77030.
 SO    Br J Cancer Suppl. 1994 Sep;23:S34-6. Unique Identifier : AIDSLINE
       MED/94355211
 AB    As a rare, sporadic disease Langerhans cell histiocytosis (LCH) presents
       a difficult problem in defining a likely etiology. Epidemiological data
       would not a priori lead one to choose a viral etiology. However, there
       are rare tumours which occur as sequelae of common infections from
       Epstein-Barr virus or human papilloma viruses. Likewise some viruses can
       cause cells to elaborate cytokines which could ultimately stimulate
       Langerhans cell growth. There is only a small amount of experimental
       data testing the hypothesis that viruses might be associated with LCH.
       The theoretical constructs surrounding this question and new data
       refuting the association are summarised.
 DE    Adenoviridae/ISOLATION & PURIF  Cytomegalovirus/ISOLATION & PURIF  DNA,
       Viral/*ISOLATION & PURIF  Herpesvirus 4, Human/ISOLATION & PURIF
       Histiocytosis, Langerhans-Cell/METABOLISM/*MICROBIOLOGY  Human
       HIV/ISOLATION & PURIF  HTLV-BLV Viruses/ISOLATION & PURIF  In Situ
       Hybridization  Parvovirus/ISOLATION & PURIF  Simplexvirus/ISOLATION &
       PURIF  Support, Non-U.S. Gov't  JOURNAL ARTICLE  REVIEW  REVIEW
       LITERATURE

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