Document 0575
 DOCN  M94A0575
 TI    In vitro studies of Schwann cell infectivity by human immunodeficiency
       virus (HIV).
 DT    9412
 AU    Ayers MM; Turnbull V; Siregar H; Crowe SM; Gonzales MF; Neuropathology
       Research Laboratory, Royal Melbourne Hospital,; Parkville, Vic.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:99 (poster no. 48).
       Unique Identifier : AIDSLINE ASHM5/94349080
 AB    Attention has recently focussed on Schwann cells as antigen presenting
       cells in inflammatory demyelinating polyneuropathy (IDPN). Whether
       Schwann cells process and present antigen following viral infection is
       of particular interest. To determine if human Schwann cells can be
       infected by HIV, cultures of Schwann cells were established from a sural
       nerve biopsy in a patient with Type 1 hereditary motor sensory
       neuropathy (HMSN). Three cultures were established over a period of
       eight weeks. Two cultures were then exposed to the Ba-L strain of HIV.
       HIV p24 was quantified in all three culture supernatants by ELISA and
       cultures double immunostained for p24 and the Schwann cell marker, S-100
       protein. The data from these experiments are preliminary but indicate
       that Schwann cells can be infected in vitro by HIV. Infection of Schwann
       cells by HIV may be an important event in the pathogenesis of
       HIV-associated peripheral neuropathy.
 DE    Antigen-Presenting Cells/*IMMUNOLOGY  Biopsy  Cells, Cultured  Human
       HIV/*PATHOGENICITY  HIV Infections/*IMMUNOLOGY  Neuropathies, Hereditary
       Motor and Sensory/PATHOLOGY  Polyradiculoneuritis/*IMMUNOLOGY  Schwann
       Cells/*IMMUNOLOGY/MICROBIOLOGY  Sural Nerve/IMMUNOLOGY/PATHOLOGY
       Virulence  MEETING ABSTRACT

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