Document 0582
 DOCN  M94A0582
 TI    Yield from upper endoscopic gastrointestinal biopsy of macroscopically
       normal mucosa in AIDS patients.
 DT    9412
 AU    Kelly M; Engelman J; Lloyd A; Jones P; Pirola R; Department of
       Infectious Diseases, Prince Henry Hospital, Little; Bay, Sydney.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:95 (poster no. 41).
       Unique Identifier : AIDSLINE ASHM5/94349073
 AB    AIM: To review the diagnostic yield from the biopsy of macroscopically
       normal mucosa seen at upper GIT endoscopy in AIDS patients with GIT
       symptoms. METHOD: The case records of 62 AIDS patients having upper GIT
       endoscopies between 6/91 and 6/93 were retrospectively reviewed.
       Clinical history; endoscopic appearance; histology and microbiology
       results were analysed. RESULTS: 147 biopsy results were evaluable; 81
       biopsies were taken from mucosa with normal endoscopic appearance.
       Significantly abnormal results were obtained from 4 biopsies; 2 of 11
       and 2 of 31 endoscopically normal oesophageal and gastric biopsies
       respectively. All 4 biopsies revealed cytomegalovirus (CMV) disease. Two
       biopsies were from patients with previously diagnosed CMV disease. None
       of the 39 macroscopically normal duodenal biopsies revealed
       significantly abnormal results. This compares with the diagnostic yield
       of 27 of 66 biopsies with abnormal endoscopic appearance. CONCLUSION: In
       AIDS patients with GIT symptoms the diagnostic yield from the biopsy of
       macroscopically normal mucosa is low particularly in patients without
       previously diagnosed GIT disease.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  AIDS-Related
       Opportunistic Infections/PATHOLOGY  Biopsy  Cytomegalovirus
       Infections/PATHOLOGY  Duodenum/PATHOLOGY  *Endoscopy, Gastrointestinal
       Gastric Mucosa/*PATHOLOGY  Gastrointestinal Diseases/PATHOLOGY  Human
       Intestinal Mucosa/*PATHOLOGY  MEETING ABSTRACT

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