Document 0585
 DOCN  M94A0585
 TI    Increase in CD4 lymphocyte numbers after splenectomy in patients
       infected with the human immunodeficiency virus.
 DT    9412
 AU    Fairley CK; Spelman D; Street A; Jennens ID; Spicer WJ; Crowe S;
       Department of Social and Preventive Medicine, Alfred Hospital,; Prahran,
       Victoria.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:94 (poster no. 38).
       Unique Identifier : AIDSLINE ASHM5/94349070
 AB    The effect of splenectomy on lymphocyte subsets was assessed by
       retrospectively examining the charts of 10 patients who were infected
       with HIV and who had undergone splenectomy. There was a significant
       increase in the mean CD4 numbers following splenectomy (mean increase of
       326/microliters, P = 0.009) the total lymphocyte numbers (mean increase
       of 1.55/ml, P = 0.001) and in the CD8 lymphocyte count (mean increase of
       968/microliters, P = 0.014). No significant difference was observed in
       the percentage CD4 lymphocytes (P = 0.95) or in the CD4:CD8 lymphocyte
       ratio (P = 0.76). We conclude that the total CD4 count increases
       significantly after splenectomy while the percentage CD4 lymphocyte
       count and CD4:CD8 lymphocyte ratio do not. Our data suggest that the CD4
       lymphocyte count overestimates the immune function in these patients,
       although our findings are not conclusive.
 DE    CD4-CD8 Ratio  Human  HIV Infections/IMMUNOLOGY/*SURGERY  *Leukocyte
       Count  Postoperative Complications/*IMMUNOLOGY  Retrospective Studies
       *Splenectomy  T4 Lymphocytes/*IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).