Document 0588
 DOCN  M94A0588
 TI    HIV infection in haemophilia.
 DT    9412
 AU    Chan T; Street A; Haemophilia Treatment Centre, Alfred Hospital,
       Prahran, Vic.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:92 (poster no. 35).
       Unique Identifier : AIDSLINE ASHM5/94349067
 AB    HIV infection in haemophilia differs in several respects from infection
       in other groups. Co-infection with Hepatitis C (HCV) and/or Hepatitis B
       (HBV) is common and its course may be modified by HIV. HIV may also
       alter the natural history of haemophilia. This paper presents data on 75
       evaluable persons with haemophilia infected with HIV between 1981 and
       1985. 59 (79%) were alive and 16 (21%) had died (July 1993). Cumulative
       incidence of AIDS was 23%. 9 (12%) had died of AIDS. No deaths were due
       to liver failure despite universal co-infection with HCV. There was no
       KS, CMV retinitis or toxoplasmosis despite sero-prevalence of 60% and
       30% respectively. There were altered immune responses to HBV in 16% of
       those co-infected with HIV/HBV. HIV exposes the risk of septic arthritis
       in haemophilia and is associated with disappearance of allo Factor VIII
       inhibitors. Because many haemophilia patients have chronic hepatitis it
       is necessary to modify investigation and prescribing habits with regard
       to AIDS management.
 DE    *Cause of Death  Comorbidity  Factor VIII/ADMINISTRATION &
       DOSAGE/ANTAGONISTS & INHIB  Hemophilia/*MORTALITY  Hepatitis
       B/MORTALITY/TRANSMISSION  Hepatitis C/MORTALITY/TRANSMISSION  Human  HIV
       Infections/*MORTALITY/TRANSMISSION  Victoria/EPIDEMIOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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