Document 0659
 DOCN  M94A0659
 TI    Neuropsychological impairment in AIDS dementia complex (ADC):
       preliminary results.
 DT    9412
 AU    Dunbar N; Brew B; National Centre in HIV Epidemiology and Clinical
       Research,; University of New South Wales, Sydney.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:53 (abstract no. SP1).
       Unique Identifier : AIDSLINE ASHM5/94348996
 AB    AIM: To develop a predictive model of neuropsychological impairment in
       ADC. METHOD: HIV+ homosexual men were recruited. Eligibility criteria
       were: CD4+ cell count < 200, no acute systemic illness,
       psychiatric/neurologic/i.v. drug history. Subjects were
       neuropsychologically and neurologically assessed at baseline and at 4
       monthly intervals for 1 year. A control group of HIV-homosexual men were
       recruited to participate in the baseline neuropsychological section of
       the study only. The neuropsychological test battery assessed the
       functions of memory, information processing, motor performance,
       conceptual flexibility, language and spatial ability. RESULTS: To date
       50 HIV+ subjects and 18 HIV- subjects have been recruited. The first
       preliminary analysis was on the neuropsychological performance of 18
       HIV+ nondemented subjects matched with the control group for age and
       years of education. The groups were compared using parametric and
       non-parametric methods. The HIV+ group performed significantly worse
       than the control subjects in the following areas: verbal and visual
       memory, motor performance, and information processing. The second
       analysis involved 23 HIV+ subjects who had completed 2 visits. The only
       significant changes were associated with a minor improvement in
       performance on some tests of memory, visuospatial ability and learning,
       probably indicative of a practice effect. CONCLUSION: This severely
       immunodeficient clinically nondemented HIV+ group had significant
       neuropsychological impairment in the areas of memory, motor performance
       and information processing. There was no progression of impairment after
       4 months. This pattern of impairment is also observed in demented
       patients, suggesting that these areas of function may be early markers
       for the development of ADC.
 DE    Adult  AIDS Dementia Complex/*DIAGNOSIS/PSYCHOLOGY  Comparative Study
       Homosexuality/PSYCHOLOGY  Human  HIV Seronegativity  HIV
       Seropositivity/DIAGNOSIS/PSYCHOLOGY  Male  *Neuropsychological Tests
       Problem Solving  Psychomotor Performance  Recall  MEETING ABSTRACT

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