Document 0676
 DOCN  M94A0676
 TI    HIV infection in recipients of blood products from donors with
       identified dates of HIV seroconversion.
 DT    9412
 AU    Ashton L; Learmont J; Luo K; Wylie B; Stewart G; Kaldor J; National
       Centre for HIV Epidemiology and Clinical Research,; Sydney.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:44 (abstract no. FE3).
       Unique Identifier : AIDSLINE ASHM5/94348979
 AB    OBJECTIVES: To study factors that influence survival time in
       HIV-infected transfusion recipients. METHODS: A registry of people with
       transfusion acquired HIV infection (TAHIV) in NSW was established by the
       Red Cross Blood Transfusion Service; annual follow-up was implemented in
       1990. From the registry a group of 6 donors were identified for whom
       approximate seroconversion dates could be established. Survival analysis
       was performed for the 25 corresponding recipients using the log rank
       test and Cox proportional hazards regression. RESULTS: Three factors
       were found to be significantly associated with increased survival rates
       in univariate and multivariate analyses. Recipients who received blood
       from donors who did not develop AIDS within 10 years appeared to survive
       significantly longer than recipients who received blood from donors who
       did (p = 0.01). Recipients aged under 50 years of age had significantly
       longer survival times than recipients aged over 50 (p < 0.01) and the
       number of transfusions was found to be inversely associated with
       survival (p < 0.01). Gender, zidovudine treatment and severity of
       illness at transfusion were not found to be significantly associated
       with survival time. CONCLUSION: Age, disease progression in the donor
       and the number of transfusions appeared to be important predictors of
       survival in people with TAHIV.
 DE    Adult  Australia/EPIDEMIOLOGY  Blood Donors/*STATISTICS & NUMER DATA
       Blood Transfusion/*MORTALITY  Cause of Death  Female  Follow-Up Studies
       Human  HIV Infections/MORTALITY/*TRANSMISSION  HIV
       Seropositivity/MORTALITY/*TRANSMISSION  Male  Middle Age  Proportional
       Hazards Models  Survival Rate  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).