Document 0702
 DOCN  M94A0702
 TI    Progressive multifocal leucoencephalopathy--the Fairfield Hospital
       experience.
 DT    9412
 AU    Marshall C; Jennens I; Fairfield Hospital, Vic.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:30 (abstract no. TC8).
       Unique Identifier : AIDSLINE ASHM5/94348953
 AB    Progressive multifocal leucoencephalopathy (PML) is a cerebral infection
       caused by JC virus occurring in immunocompromised people. It has been
       well described in transplant recipients requiring immunosuppressive
       therapy and more recently in people immunosuppressed with human
       immunodeficiency virus (HIV). PML is estimated to occur in 1% of persons
       with AIDS. Fairfield Infectious Diseases Hospital has treated 716 people
       with Category IV disease or AIDS. PML has been diagnosed in 12 of these
       patients. We conducted a search of hospital records to determine the
       clinical features of patients with HIV infection and PML. As opposed to
       transplant recipients where PML is multifocal, PML complicating HIV
       infection presented with distinct neurological deficits with unifocal
       lesions on brain imaging on 8 occasions. All patients were homosexual
       males. Median CD4 count at presentation was 45 (range 10-330), and in
       9/12 patients PML was their AIDS defining illness. Median survival
       following a diagnosis/presentation was 2 months (range 0.5-6 months).
       Three patients received treatment with IV Ara C, but treatment did not
       appear to improve neurological deficits or prolong survival.
 DE    AIDS Dementia Complex/*DIAGNOSIS/IMMUNOLOGY/MORTALITY  Follow-Up Studies
       Human  Leukocyte Count  Leukoencephalopathy, Progressive
       Multifocal/*DIAGNOSIS/IMMUNOLOGY/  MORTALITY  Neurologic Examination
       Polyomavirus hominis 2  Survival Rate  T4 Lymphocytes/IMMUNOLOGY
       MEETING ABSTRACT

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