Document 0705
 DOCN  M94A0705
 TI    Resistant fungal infections in AIDS--an emerging problem.
 DT    9412
 AU    Woolley I; Fuller A; Franklin C; Hale C; Vujovic O; Russell P; Spelman
       D; Spicer WJ; Department of Microbiology and Infectious Diseases,
       Alfred; Hospital, Prahran.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:28 (abstract no. TC6).
       Unique Identifier : AIDSLINE ASHM5/94348950
 AB    1. CANDIDIASIS. We discuss 3 patients who developed severe symptomatic
       oral candidiasis. Clinical resistance to ketoconazole and fluconazole
       occurred over time, necessitating the use of intravenous amphotericin in
       two patients. Disc sensitivity testing of their isolates with
       Neosensitabs confirmed the resistance. 2. CRYPTOCOCCOSIS. We discuss one
       patient with cryptococcaemia and not meningitis treated with fluconazole
       who relapsed months later. Disc sensitivity testing of the isolate with
       Neosensitabs revealed the cryptococcus was initially intermediate and
       later became resistant to fluconazole. He is now being treated with
       itraconazole. Fungal resistance is clearly an emerging problem in AIDS
       patients. We find there is good correlation with our disc sensitivity
       testing and clinical outcome.
 DE    Amphotericin B/*ADMINISTRATION & DOSAGE  AIDS-Related Opportunistic
       Infections/*DRUG THERAPY  Candidiasis, Oral/*DRUG THERAPY
       Cryptococcosis/*DRUG THERAPY  Drug Resistance, Microbial  Drug Therapy,
       Combination  Fluconazole/*ADMINISTRATION & DOSAGE  Fungemia/*DRUG
       THERAPY  Human  Infusions, Intravenous  Itraconazole/*ADMINISTRATION &
       DOSAGE  Ketoconazole/*ADMINISTRATION & DOSAGE  MEETING ABSTRACT

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