Document 0714
 DOCN  M94A0714
 TI    HIV related dementia.
 DT    9412
 AU    Strain J
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:23 (abstract no.
       FPI-4). Unique Identifier : AIDSLINE ASHM5/94348941
 AB    This paper will address the prevalence, the etiology, and the treatment
       of the organic mental disorders that accompany HIV infection, with
       special attention to the dementias. Late-stage HIV infection is
       frequently associated with a syndrome of progressive dementia,
       presumably etiologically related to the virus activity in the brain,
       although it may occur at any stage of the disease, even as the
       presenting symptom. Navia and Price described this clinical stage as
       AIDS dementia complex (ADC). Macrophages, microglia and neuronal cells
       have been found to be affected by the virus in autopsy specimens.
       Studies describe that the prevalence of HIV dementia among AIDS patients
       ranges from 50% to 70%. Early diagnosis is complicated by the relative
       nonspecificity of the most common symptoms: short term memory
       dysfunction, mild confusion, psychomotor slowing, and headache, which
       can be confused with depression or reactions to the illness. Advanced
       dementia in HIV patients is characterised by severe memory loss,
       incoordination, tremor, hyper-reflexion, disturbances of gait, paranoid
       states, and seizures. Chemotherapeutic and psychotherapeutic management
       of these organic states will be discussed.
 DE    AIDS Dementia Complex/*DIAGNOSIS/PATHOLOGY/THERAPY  Brain/PATHOLOGY
       Combined Modality Therapy  Human  Macrophages/PATHOLOGY
       Microglia/PATHOLOGY  Neurologic Examination  Neurons/PATHOLOGY
       Neuropsychological Tests  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).