Document 0719
 DOCN  M94A0719
 TI    Unravelling the molecular biology of HIV.
 DT    9412
 AU    Rosenberg M; SmithKline Beecham Pharmaceuticals, King of Prussia, PA;
       19406-0939.
 SO    Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:20 (abstract no.
       TPI-5). Unique Identifier : AIDSLINE ASHM5/94348936
 AB    HIV is a genetically complex retrovirus which can integrate into the
       genome of its human host and thereby remain hidden from immune
       surveillance or replicate slowly to achieve its chronic infection
       process. The advent of the recombinant DNA technologies have allowed
       identification, molecular dissection and characterisation of many
       aspects of the virus, including its structure, life cycle and
       interaction with the human host. The emerging picture remains a daunting
       one. The virus uses intricate mechanisms to regulate its growth, genetic
       diversity and deceptive interaction and eventual destruction of the
       host. Although a molecular description of HIV has certainly revealed
       many vital features of the virus and has helped to identify those which
       might serve as a focus of certain control strategies, the present
       picture still falls short of revealing the full dimensions of the
       challenge presented by AIDS.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*MICROBIOLOGY  Human
       HIV/*GENETICS/IMMUNOLOGY  HIV Infections/IMMUNOLOGY/*MICROBIOLOGY
       Molecular Biology  Virus Replication/GENETICS/IMMUNOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).