Document 0901
 DOCN  M94A0901
 TI    Blood transfusion induced immunodeficiency and AIDS in haemophilia.
 DT    9412
 AU    Guerra A; Banco Central de Sangre, Mexico.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):255 (abstract no. PC0386). Unique
       Identifier : AIDSLINE ICA10/94371674
 AB    OBJECTIVE: To analize the immune status in the abscence and presence of
       HIV infection in haemophiliac patients and the rate of progression to
       AIDS in HIV-Positive Haemophiliac (H+HP) and No-Haemophiliac (H+NHP)
       Patients. METODE: Review of the reported immune status (both cell and
       humoral mediated immune responses) in haemophilia in abscence and
       presence of HIV infection and the rate of progression to AIDS in H+HP
       and H+NHP, reported elsewhere. RESULTS: There are several reports about
       impaired cell and humoral mediated immunity, evaluated by means of the
       dinitrochlorobenzene skin test, Fc dependent monocyte phagocytic
       function inhibition, peripheral blood mononuclear cell proliferation,
       capacity to produce IL-2 and T-cells subsets, between others, in
       haemophilia in abscence of HIV infection. These changes are in
       association with the consumption of clotting factor concentrates and its
       purity. With this baseline blood transfusion induced immunodeficiency,
       the rate of progression to AIDS in H+HP has been reported between 20-5%
       compared with a 50% rate in H+NHP in a ten years follow-up basis.
       DISCUSSION AND CONCLUSIONS: H+HP have a baseline blood transfusion
       induced immunodeficiency that is not an adverse factor to progression to
       AIDS, as expected, when compared with the rate of progression in H+NHP.
       These data suggest that this baseline immunodeficiency favor a slow
       progression to AIDS, maybe by means of the inhibition of the phagocytic
       activity of macrophages and the activation of CD4+ T cells necessary for
       HIV replication.
 DE    Acquired Immunodeficiency Syndrome/*ETIOLOGY  Blood Transfusion/*ADVERSE
       EFFECTS  Follow-Up Studies  Hemophilia/COMPLICATIONS/*IMMUNOLOGY  Human
       HIV Infections/*TRANSMISSION  *Immune Tolerance  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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