Document 0904
 DOCN  M94A0904
 TI    HIV & HBsAg in transfused patients with sickle cell anaemia (SCA) in
       Lagos, Nigeria.
 DT    9412
 AU    Animashaun R; Akinsete I; Njoku O; Department of Haematology & Blood
       Transfusion, Lagos University; Teaching Hospital.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):254 (abstract no. PC0380). Unique
       Identifier : AIDSLINE ICA10/94371671
 AB    OBJECTIVE: To determine the prevalence of blood transfusion induced HIV
       AND HBsAg among transfused and non-transfused patients with SCA.
       MATERIALS: 240 patients with SCA were studied. Age range 5-43 yrs. from
       5 clinics in Lagos Metropolis. 160 SCA had been transfused with blood in
       the previous 5 yrs. and 80 had never had blood transfusion. METHODS:
       Serum samples of SCA were screened for HIV 1&2 by Wellcozyme Elisa and
       those repeatedly positive were confirmed by Western blot. Screening for
       HBsAg was also by Wellcozyme Elisa. RESULT: In those who had received
       blood transfusion, 6/160 (3.8%) were HIV positive by both Elisa and
       Western blot. 2 (1.3%) were HIV-1 and 4 (2.5%) were HIV-2 positive. In
       the same transfused group HBsAg was positive in 32/160 (20%). All those
       who had never been transfused (80) were seronegative for HIV & HBsAg.
       The mean number of transfusions was 4.4 S.D +/- 2.8 and the highest
       number occurred in the 5-14 yrs. age group in which prevalence of HIV
       was (3.1%) and prevalence of HBsAg was (7.6%). CONCLUSION: In a low
       prevalence country like Nigeria (General population 1%), Blood
       Transfusion continues to be hazardous especially in children and young
       adults who suffer from Haemoglobinopathies. Efforts are needed to make
       transfusion safer and to educate Medical Personnels on the need for
       alternatives in the management of patients with haemoglobinopathies.
 DE    Adolescence  Adult  Anemia, Sickle Cell/*COMPLICATIONS/THERAPY  Blood
       Transfusion/*ADVERSE EFFECTS  Child  Child, Preschool  Hepatitis
       B/EPIDEMIOLOGY/TRANSMISSION  Hepatitis B Surface Antigens/*ANALYSIS
       Human  HIV Infections/EPIDEMIOLOGY/*TRANSMISSION  Nigeria/EPIDEMIOLOGY
       Prevalence  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).