Document 0907
 DOCN  M94A0907
 TI    Natural history of HIV-1 infected patients in Japan. Study Group of the
       Ministry of Health and Welfare for the Prevention and Treatment of HIV
       Infections.
 DT    9412
 AU    Mimaya J; Meguro T; Tatsunami S; Fujimura Y; Takamatsu J; Fukutake K;
       Yanagawa H; Shizuoka Children's Hospital, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):253 (abstract no. PC0374). Unique
       Identifier : AIDSLINE ICA10/94371668
 AB    OBJECTIVE: The Natural History committee has performed a follow-up over
       time and an analysis of the clinical course and laboratory data of HIV
       carriers. MATERIALS AND METHODS: The study subjects were HIV carriers
       and hemophiliacs who were outpatients in hospitals affiliated with
       members of the study group. As of 1988, 1,081 HIV-Ab positive cases and
       1,146 negative cases had been registered. Clinical symptoms and
       laboratory findings were analyzed twice each year between 1985 and 1993.
       RESULTS AND CONCLUSIONS: 1) The CD4 counts in the HIV-Ab positive group
       have continued to decrease in an approximately linear manner since 1985.
       The overall mean decrease is 30 cells/microliter/y. Immunoglobulins
       tended to increase in the HIV infected group. 2) The stages of CDCIII+IV
       were found in 3-5% of the registered carriers in 1985. This figure has
       risen to 27% in 1993. 3) The cumulative AIDS incidence in the 10 years
       since the infection was calculated as 18%. 4) The P24 antigen positive
       rate was 20% in the cases tested. HIV-Ab positive cases were all
       positive for provirus DNA. Silent infection cases were not found. Serum
       HIV-RNA was detected by RT-PCR in all of the HIV-Ab positive cases. 5)
       In a comparison between the CDCII and IV groups, the isolation rate in
       the CDCIV group was significantly higher than that in the CDCII group.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY  Carrier
       State/*IMMUNOLOGY  Hemophilia/COMPLICATIONS  Human  HIV Core Protein
       p24/ANALYSIS  HIV Infections/*IMMUNOLOGY  HIV Seropositivity
       Japan/EPIDEMIOLOGY  Leukocyte Count  T4 Lymphocytes/IMMUNOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).