Document 0944
 DOCN  M94A0944
 TI    Clinical epidemiology of HIV infection in the follow up study in the
       Tokyo Japan Metropolitan area. HIV Epidemiology Research Committee of
       the MHW.
 DT    9412
 AU    Matsumoto T; Shiokawa Y; Shimada K; Negishi M; Matsuda J; Mizogami M;
       Oosato K; Hamashima N; Sakurai Y; Dept. of General Medicine, Juntendo
       Univ. School of Medicine,; Tokyo, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):245 (abstract no. PC0340). Unique
       Identifier : AIDSLINE ICA10/94371631
 AB    OBJECTIVE: To analyze epidemiological trends and natural history of
       HIV/AIDS in the Tokyo Metropolitan area. METHODS: In 1991 questionnaires
       were distributed to all hospitals in the Tokyo Metropolitan area
       requesting information on all current and past cases of HIV/AIDS.
       Reports from each hospital were then collated, excluding HIV/AIDS cases
       infected through blood products. Later, cases of HIV/AIDS diagnosed in
       1992 and 1993 were added. Patients' backgrounds, stages of disease
       development, and general rate of survival, etc. were also analyzed.
       RESULTS: The number of registered HIV/AIDS cases was 481. This number
       represents approximately 35% of total HIV/AIDS cases (excluding cases
       infected through blood products) reported to the AIDS Surveillance
       Committee of the Ministry of Health and Welfare. Japanese citizens make
       up 67.5% of the reported cases. Risk factors were; male homosexual
       contact: 46.5%, heterosexual contact: 37.9%, blood transfusion: 3.1%,
       IVDU: 1.6%, perinatal transmission: 0.8%. At first diagnosis, stage
       classification was AC: 62.2%, ARC: 12.0%, AIDS: 23.2%. AIDS symptoms
       were; PCP: 44.8%, KS: 12.5%, HIV encephalopaphy: 11.5%. The three year
       survival rate (Kaplan-Meier method) from initial diagnosis was; AC
       group: 91.2%, ARC group: 28.2%, AIDS group: 11.4%. Finally, the
       reporting rate to the AIDS Surveillance Committee was 79.7%. DISCUSSION
       AND CONCLUSION: One feature of the HIV/AIDS situation in Japan has been
       that so far 60% of all reported cases were hemophiliacs. However,
       current trends indicate that sexual contact has become the main route of
       HIV/AIDS in Japan. These results, 481 non-hemophiliac HIV/AIDS cases in
       the Tokyo area, present significant insight into the current situation
       of HIV/AIDS in Japan as a whole.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY/MORTALITY  AIDS-Related
       Complex/EPIDEMIOLOGY  Blood Transfusion/ADVERSE EFFECTS
       Hemophilia/COMPLICATIONS  Homosexuality  Human  HIV
       Infections/CONGENITAL/*EPIDEMIOLOGY/MORTALITY/TRANSMISSION  Risk Factors
       Sexually Transmitted Diseases, Viral/EPIDEMIOLOGY  Survival Rate
       Tokyo/EPIDEMIOLOGY  MEETING ABSTRACT

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