Document 0989
 DOCN  M94A0989
 TI    Critical analysis of hepatic biopsies in AIDS.
 DT    9412
 AU    Lima BD; Jurado E; Pinho P; Moreira P; Paiva D; State university of Rio
       de Janeiro, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):234 (abstract no. PB0951). Unique
       Identifier : AIDSLINE ICA10/94371586
 AB    OBJECTIVE: To evaluate hepatic biopsies that were done in AIDS patients
       according to their diagnostic potential, using two different techniques
       and comparing their effectiveness. METHODS: Fifty-three biopsies were
       performed between 1985 and 1993 to check for long-lasting fever and/or
       hepatosplenomegaly and/or altered hepatic function tests. The biopsies
       were carried out using needles through blind percutaneous punctures or
       by means of laparoscopically guided technique. The results that were
       considered as positive were those that originated therapeutic changes.
       The impaired student's T test was applied in the analysis of parametric
       data and the chi-square test for significance was used for absolute
       numbers. The Sp's < 0.01 were considered statistically significant. The
       Lp's < 0.05 were considered as borderline and the NSp's > 0.05 were
       considered as non-significant. RESULTS: The positive results were:
       tuberculosis 10 (38.46), granulomatous hepatitis 5 (19.23%), active
       chronic hepatitis 3 (11.53%), cirrhosis 3 (11.53%), cryptococcosis 3
       (11.53%), cytomegalovirosis 1 (3.84%), histoplasmosis 1 (3.84%), which
       corresponded to 26 out of the total amount of samples that were examined
       (49.05%). The blind biopsy procedure diagnosed 10 out of 21 cases
       (47.5%) and the laparoscopy procedure diagnosed 16 out of 32 cases
       (50%), p > 0.05. There was no statistical difference between the two
       groups regarding the positiveness of the biopsies when the age and
       hepatic function test parameters were compared in each group. The
       existence of fatty liver was observed in 20 biopsies (37.7%), and it was
       not due to the use of any hepatotoxic drug (p > 0.05). The same can be
       said about the non-specific findings. DISCUSSION AND CONCLUSIONS: The
       efficiency of both techniques was about 50%. The age and the altered
       hepatic function tests parameters could not determine whether the
       biopsies were positive or not.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  AIDS-Related
       Opportunistic Infections/DIAGNOSIS  Biopsy/*METHODS  Comparative Study
       Hepatitis/DIAGNOSIS  Human  Laparoscopy  Liver/*PATHOLOGY  Liver
       Cirrhosis/DIAGNOSIS  Liver Diseases/*DIAGNOSIS  Tuberculosis,
       Hepatic/DIAGNOSIS  MEETING ABSTRACT

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