Document 1032
 DOCN  M94A1032
 TI    Experience with nutritional support in patients with wasting syndrome in
       advanced AIDS.
 DT    9412
 AU    Gallegos-Perez H; Feregrino-Goyos M; Alvarado Diez R; Eid Lidt G;
       Clinica ISI de Norteamerica, Mexico D.F., Mexico.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):224 (abstract no. PB0909). Unique
       Identifier : AIDSLINE ICA10/94371543
 AB    OBJECTIVES: Cost-benefit analysis of enteral Nutrition support (EN)
       compared with Total Parenteral nutrition (TPN) in patients with wasting
       syndrome in advanced AIDS with a decrease of more than 20% of body
       weight loss and infectious or tumoral complications. We do evaluate
       correlation between better nutrition and count of CD4 cells and
       Karnofsky index. METHODS: 100 patients were studied, all with a
       reduction of more than 20% of body weight for a period from two weeks to
       3 months until improvement of undernutrition. CD4, Karnofsky index
       weight modifications cost of nutritional support and metabolic or
       infectious complications related to the Nutritional backup and mortality
       rate were evaluated. Group I of 40 patients that received TPN in the
       patients who presented intollerance to oral way due to esophagitis
       caused by candida or CMV, hypersecretory diarrhea with excreta between 2
       to 7 liters by day, surgery, or incohercible emesis. 20 patients
       received TPN with dextrose 50%, ramificated chain aminoacids, and medium
       chain tryglicerides (MTC); Other 20 received similar composition with
       long chain triglycerides (LTC). Group II was formed by 60 patients and
       received enteral nutrition (EN) by oral way or nasoyeyunal tube. 25
       patients received polymeric formula without fiber, 5 patients elemental
       formula, and 20 patients received IMMUNONUTRITION with MTC, A.A.
       enriched with arginine and gluthamine. RESULTS: In group I the average
       duration of TPN was 15.6 days (from 8 to 90), the increse of weight in
       one month was 8 kg (from 3 to 25 kg), Karnofsky index raised 20 points,
       CD4 increase in un medium of 25 cells (from 0 to 88), the cost of
       therapy was $3000.00 dollars, and 7 patients passed away, 6 with liver
       disfunction and one by pancreatitis, and 2 catheter infection,
       hyperglicemia in 8 patients. Group II had an average duration of 120
       days (from20 to180 cost $2000.00DLLS.. weight increase 4 kg, I.I. in 15
       points and CD4 increase only w. IMMUNONUT.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Body Weight
       Cachexia/ETIOLOGY/*THERAPY  Comparative Study  Cost-Benefit Analysis
       *Enteral Nutrition/ECONOMICS  Human  Karnofsky Performance Status
       Leukocyte Count  *Parenteral Nutrition, Total/ECONOMICS  Syndrome  T4
       Lymphocytes  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).