Document 1035
 DOCN  M94A1035
 TI    Vitamin B12 and folate in AIDS.
 DT    9412
 AU    Bieber S; Fremont S; May T; Sarem F; Gerard P; Nicolas JP; Canton P;
       Dept. of biochemistry, CHU-Nancy-France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):223 (abstract no. PB0905). Unique
       Identifier : AIDSLINE ICA10/94371540
 AB    OBJECTIVE: To assess vitamin B12 and folate status of HIV seropositive
       patients. METHODS: A group of 106 HIV-1 positive patients were included
       in this study and ranged according to CDC 1993 (40 stage A, 36 stage B,
       30 stage C). The following parameters were determined: vitamin B12 (B12)
       and its seric binder (apo-transcobalamin II, apo TCII), seric folate,
       neopterin. RESULTS AND DISCUSSION: TABULAR DATA, SEE ABSTRACT VOLUME.
       Neopterin reflects the stimulation of cellular immunity (Fig. 1). A
       folate deficiency is shown in 31% of the patients, without any
       significant difference between the three groups. Among these folate
       deficiency patients, 80% present an elevated neopterin level (> 10
       nmol/l). This could suggest the antifolate activity of neopterin. A low
       B12 level is observed in 9% of asymptomatic patients and 30% of group B
       and C patients. This level decrease proportionally to CD4 count and is
       inversly proportional to B12 seric binder level (apo TCII). B12
       deficiency could be due to nutritional defect or to malabsorption. An
       abnormality of intrinsic factor or of its receptor could be involved.
       Schilling test will allow to valid this hypothesis.
 DE    Biopterin/ANALOGS & DERIVATIVES/BLOOD  Folic Acid
       Deficiency/BLOOD/*ETIOLOGY  Human  HIV
       Seropositivity/BLOOD/*COMPLICATIONS/IMMUNOLOGY  Transcobalamins/ANALYSIS
       Vitamin B 12/BLOOD  Vitamin B 12 Deficiency/BLOOD/*ETIOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).