Document 1038
 DOCN  M94A1038
 TI    Nutritional parameters and immune status in a group of drug dependent
       males with HIV infection in a different clinical stage.
 DT    9412
 AU    Verani DA; Andreoni M; Moggio G; Salatino A; de Saraca M; Dept. of
       Infectious Diseases-Ospedale degli Infermi, Biella,; Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):223 (abstract no. PB0904). Unique
       Identifier : AIDSLINE ICA10/94371537
 AB    OBJECTIVE--to ascertain whether there are significant statistical
       differences in some nutritional parameters in relation to HIV infection
       at different stages according to the CDC classification to correlate
       nutritional parameters with CD4+ lymphocytes. METHODS--seventy eight HIV
       infected drug-dependent males were divided into 2 groups: group 1 (37
       subjects fulfilled the criteria for CDC class II) and group 2 (31
       subjects fulfilled the criteria for CDC class III and IV). The following
       parameters were studied body mass index (BMI), total cholesterol (CH),
       albumin (ALB), transferrine (TR), haemoglobin (HB), haematocrit (HCT),
       and number of CD4+ lymphocytes. The t test was used for statistical
       analisis for non paired data; the chi square and the linear coefficient
       of Person were also calculated. Results were as follow: TABULAR DATA,
       SEE ABSTRACT VOLUME. CONCLUSION--When comparing the average values of
       the nutritional parameters between the two groups, a statistically
       significant difference between the nutritional status in early and late
       stages of HIV infection is apparent. We draw attention however that
       already in cases with asymptomatic infection, cholesterol levels are
       rather low as it occurs in other infectious processes. An altered
       nutritional state is already present in the early stages of infection.
       The nutritional deficit highlighted in group 2 subjects is concomitant
       to the cell mediated immune deficit (statistically significantly lower
       CD4 counts). A positive correlation was found between each of the
       nutritional parameters studied and the number of CD4+ lymphocytes. The
       worsening of nutritional parameters indices may therefore be considered
       a further negative prognostic sign in HIV infection.
 DE    Body Mass Index  Cholesterol/BLOOD  Hemoglobins/ANALYSIS  Human  HIV
       Infections/COMPLICATIONS/*IMMUNOLOGY/*METABOLISM  Leukocyte Count  Male
       *Nutritional Status  Serum Albumin/ANALYSIS  Substance
       Abuse/*COMPLICATIONS  Transferrin/ANALYSIS  T4 Lymphocytes  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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