Document 1039
 DOCN  M94A1039
 TI    Effects of megestrol acetate therapy upon body composition and serum
       testosterone in AIDS.
 DT    9412
 AU    Engelson ES; Tierney AR; Pi-Sunyer FX; Kotler DP; St. Luke's-Roosevelt
       Hosp, NY, NY 10025.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):222 (abstract no. PB0900). Unique
       Identifier : AIDSLINE ICA10/94371536
 AB    OBJECTIVE: To evaluate the effects of megestrol acetate (MA) upon body
       composition and total serum testosterone (T). METHODS: We evaluated 11
       AIDS patients receiving MA (100, 400, 800 mg/day) over 3 months, and
       compared results to 14 AIDS (C) undergoing longitudinal followup without
       therapy. Body cell mass (BCM) and fat content were determined by
       bioimpedance analysis (RJL101) in MA, while BCM was estimated by whole
       body counting of 40K and fat by anthropometric measurements in C. T was
       determined by radioimmunoassay. RESULTS: Baseline, weight, fat, BCM, and
       T were similar in MA and C. Over 12 weeks, MA gained an average of 4.7
       kg of weight (p < 0.001 vs base), 0.4 kg BCM (NS), and 2.8 kg of fat, (p
       = 0.005) whereas C lost 0.7 kg of weight (NS), 0.8 kg BCM (NS), and
       gained an average of 1.2 kg fat (NS). Of the weight gained in MA, 81%
       consisted of fat while 19% consisted of BCM. During MA treatment, T fell
       significantly (p < 0.001). In contrast, T was stable in C. The changes
       in T were similar at all doses of MA. DISCUSSION AND CONCLUSIONS: MA
       increases body weight and decreases T. Fat accumulation in MA may be the
       result of a decreased anabolic effect mediated by the decrease in T.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*DRUG THERAPY  Body
       Composition/*DRUG EFFECTS  Body Weight/DRUG EFFECTS  Human
       Megestrol/*ANALOGS & DERIVATIVES/PHARMACOLOGY/THERAPEUTIC USE
       Testosterone/*BLOOD  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).