Document 1042
 DOCN  M94A1042
 TI    Alterations in hydration in HIV-infection.
 DT    9412
 AU    Babameto G; Kotler DP; Burastero S; Wang J; Pierson RN; St.
       Luke's-Roosevelt, NY, NY 10025.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):222 (abstract no. PB0902). Unique
       Identifier : AIDSLINE ICA10/94371533
 AB    OBJECTIVE: To determine hydration status in HIV-infected people.
       METHODS: We measured total body water (TBW) in 102 HIV+ and 90 control
       subjects using indicator dilution (3H2O), as well as bioimpedance
       analysis (RJL 101A). RESULTS: Controls had higher TBW and TBW/height
       than HIV+ (p < 0.05). HIV+ with malabsorption were more dehydrated than
       those without malabsorption (20.6 +/- 2.8 vs 23.2 +/- 3.1, liters/meter,
       mean +/- sd, p < 0.001), or controls (24.2 +/- 2.6, p < 0.001). Average
       TBW was more than 6 liters lower in malabsorbers than in controls.
       Forty-four percent of patients with malabsorption were below the lower
       limits of normal for TBW/ht, compared to 11% of patients without
       malabsorption and 4% of controls (p < 0.001). The results by indicator
       dilution and BIA correlated strongly (r2 = 0.71, p < 0.0001). BIA was
       able to predict significant dehydration with a sensitivity of 67%,
       specificity of 80%, positive predictive value of 71%, and negative
       predictive value of 76%. CONCLUSIONS: 1) Dehydration is common in
       HIV-infection, 2) dehydration is predominantly found in patients with
       malabsorption, 3) BIA may be an adequate alternative to indicator
       dilution in the analysis of hydration status.
 DE    Comparative Study  Dehydration/ETIOLOGY  Electric Impedance  Human  HIV
       Infections/COMPLICATIONS/*METABOLISM  Indicator Dilution Techniques
       Malabsorption Syndromes/ETIOLOGY  Water/*METABOLISM  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).