Document 1043
 DOCN  M94A1043
 TI    Zinc and copper levels in children with HIV wasting syndrome.
 DT    9412
 AU    Coetano Neto S; Della Negra M; Queiroz W; Lian YC; Amancio O; Braga JP;
       Fisberg M; Inst. Infect. Emilio Ribas, Sao Paulo, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):221 (abstract no. PB0899). Unique
       Identifier : AIDSLINE ICA10/94371532
 AB    OBJETIVES: We measured micronutrients (zinc, copper) values in
       pediatrics patients with AIDS (P2-CDC) to determine whether
       micronutrient deficiencies were associated with the wasting syndrome
       (CDC). METHODS: Serum from 31 children (8 months--5 years) patients was
       evaluated for concentration of zinc and copper (atomic absortion
       spectrophotometry). Comparisons were made, in this group, between
       children with wasting sindrome and children with non-wasting status. The
       control group was based in 23 children HIV negative and eutrophics from
       the same environment. RESULTS: With application of Waterlow criteria
       (weight/height), we obtained 18 (59%) children with wasting status (W)
       and 13 (41%) with non-wasting status (NW). Mean serum levels for zinc
       were 107.22 mcg/dl in group W and 125.28 mcg/dl in group NW. Copper
       levels were 160.55 mcg/dl (group W) and 170.76 mcg/dl (group NW). Group
       control the results were: zinc = 108.70 mcg/dl and copper = 142.17
       mcg/dl. DISCUSSION AND CONCLUSIONS: Decreased micronutrients
       concentrations are common in adults HIV infected patients. In HIV
       positive children, we didn't find statistics differences for copper
       between two groups (W and NW) (p = 0.1). Levels for zinc were
       significantly lower in group with wasting status (p = 0.01). Comparisons
       between group seronegative and group with AIDS, didn't show statistics
       differences for zinc (p = 0.4) and copper (p = 0.06) values. Study must
       be continued to conclude about the relantionship of micronutrients,
       nutritional status and children with HIV infection.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/*COMPLICATIONS
       Cachexia/*BLOOD/*ETIOLOGY  Child  Copper/*BLOOD  Human  Infant  Syndrome
       Zinc/*BLOOD  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).