Document 1044
 DOCN  M94A1044
 TI    The status of natural coagulation inhibitors in hemophiliacs with HIV
       infection.
 DT    9412
 AU    Saito M; Siobara S; Asakura H; Matsuda T; Third Department of Internal
       Medicine, Kanazawa University School; of Medicine, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):221 (abstract no. PB0897). Unique
       Identifier : AIDSLINE ICA10/94371531
 AB    OBJECTIVE: Thrombosis is one of the complications in patients with HIV
       infection. The purpose of this study is to determine the status of
       natural coagulation inhibitors and to examine whether thrombotic
       tendency is exists or not in HIV-infected patients. METHODS: Eight
       HIV-infected men with hemophilia A or hemophilia B and age-matched 10
       healthy male controls were studied. Plasma concentrations of
       anti-thrombin III (AT III) activity, heparin cofactor II (HC II)
       activity, Protein C (PC) activity, total and free protein S (PS)
       antigen, and C4b-binding protein were determined in patients and
       controls. Serum albumin level and CD4+ lymphocyte count were also
       measured as routine laboratory tests. RESULTS: The mean value of serum
       albumin was 43 g/l and the mean CD4+ lymphocyte level was
       234/microliters in HIV-infected patients. The mean values of ATIII, HC
       II, PC, total PS and free PS were significantly lower in HIV infected
       patients than in controls. The mean level of C4b-binding protein in
       patients was normal. The concentration of AT III was only significantly
       correlated with CD4+ lymphocyte. No correlations were seen between the
       concentrations of other coagulation inhibitors and CD4+ lymphocyte
       counts and CDC classification. DISCUSSION AND CONCLUSION: The
       concentrations of coagulation inhibitors in hemophiliacs with HIV
       infection were significantly lower than in controls. These suggest that
       HIV-infected patients may be expected to be increased risk of thrombotic
       tendency and the concentration of ATIII was only significantly
       correlated with degree of immunodeficiency of all coagulation
       inhibitors.
 DE    Anticoagulants/*BLOOD  Antithrombin III/ANALYSIS  Christmas
       Disease/*BLOOD/*COMPLICATIONS  Hemophilia/*BLOOD/*COMPLICATIONS  Heparin
       Cofactor II/ANALYSIS  Human  HIV Infections/*BLOOD/*COMPLICATIONS  Male
       Protein C/ANALYSIS  Protein S/ANALYSIS  MEETING ABSTRACT

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