Document 1046
 DOCN  M94A1046
 TI    Prevalence of nutritional deficiencies in patients with HIV-1 infection.
 DT    9412
 AU    Tomaka FL; Cimoch PJ; Reiter WM; Keller RJ; Berger DS; Piperado J;
       Nemechek PM; Loss SD; Houghton RA; Center for Special Immunology, Ft.
       Lauderdale, Florida.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):221 (abstract no. PB0898). Unique
       Identifier : AIDSLINE ICA10/94371529
 AB    OBJECTIVE: To assess the prevalence of selected vitamin, mineral and
       protein deficiencies in HIV positive patients in a private practice
       out-patient setting. METHODS: We determined the T4 cell count and
       fasting (12 hours) serum levels of 449 HIV positive patients for 18
       different vitamins, minerals and proteins. RESULTS: When stratified by
       T4 cell counts, 129 (29%) of the patients had T4 counts greater than
       500, 125 (28%) had T4 counts between 200-500, and 195 (43%) had T4
       counts less than 200. One or more nutritional deficiencies were found in
       182 (40%) of the patients. The three subgroups, T4 > 500, 200-500, <
       200, each had a similar prevalence of nutrient deficits, 38%, 41%, and
       42% respectively. Of all patients studied, 77 (17.1%) had more than one
       deficit. In these 77 patients, multiple nutritional deficiencies were
       noted in 12.4% of patients with T4 counts of more than 500; 20% of
       patients with T4 counts between 200-500 and 18.5% of patients with T4
       counts of less than 200. Deficiencies noted in > 5% of patients included
       transferrin (14.7%), betacarotene (10.7%), selenium (7.1%), RBC
       magnesium (5.8%), Vitamin B6 (5.8%) and Vitamin B1 (5.1%). Deficiencies
       noted in < 5% of patients included copper, zinc, pre-albumin, retinol
       binding protein and vitamins B12, A, C, B2 and E. The RBC folate,
       carnitine, and c-reactive protein were not diminished in any of the
       patients screened. CONCLUSIONS: Numerous vitamin and mineral
       deficiencies occur in HIV disease at all stratifications of T4 cell
       count. Multiple deficits were more common in patients with T4 cell
       counts < 500. The most common deficiencies identified were of
       transferrin, betacarotene, selenium, RBC magnesium, Vitamin B6, and
       Vitamin B1. It is important to screen all HIV infected individuals for
       nutrient deficiencies as there can be significant morbidity associated
       with such deficits. The effect of select deficiencies on immune system
       function warrants further study.
 DE    Carotene/BLOOD  Deficiency Diseases/*COMPLICATIONS  Human  HIV
       Seropositivity/*COMPLICATIONS  Leukocyte Count  Magnesium
       Deficiency/COMPLICATIONS  Pyridoxine Deficiency/COMPLICATIONS
       Selenium/BLOOD  Thiamine Deficiency/COMPLICATIONS
       Transferrin/DEFICIENCY  T4 Lymphocytes  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).