Document 1047
 DOCN  M94A1047
 TI    The effect of micronutrient intake on survival in HIV-1 infection.
 DT    9412
 AU    Tang AM; Graham NM; Saah AJ; Johns Hopkins School of Public Health,
       Baltimore, MD.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):220 (abstract no. PB0894). Unique
       Identifier : AIDSLINE ICA10/94371528
 AB    OBJECTIVE: This study examines the relation between dietary and
       supplemental micronutrient intake and subsequent mortality in
       participants of the Baltimore/Washington, DC site of the Multicenter
       AIDS Cohort Study. METHODS: Included in the study were 280 HIV-positive
       gay/bisexual men who completed a self-administered semiquantitative food
       frequency questionnaire at the baseline study visit (1984). Levels of
       daily micronutrient intake were examined in relation to subsequent
       mortality (n = 121) over the 8 year follow-up period using Kaplan-Meier
       survival curves and Cox proportional hazards models, adjusting for age,
       presence of symptoms, CD4+ lymphocyte count, energy intake, and use of
       antiretrovirals. RESULTS: The highest quartiles of total intake (from
       food and supplements) of vitamins B6 (relative hazard (RH) = 0.59, 95%
       confidence interval (CI) 0.37-0.93) and C (RH = 0.62, 95% CI =
       0.39-0.98) were significantly associated with a decreased mortality
       rate. In addition, the highest quartiles of total intake of vitamins B1,
       B2, and niacin demonstrated a marginally significant 30-40% decrease in
       mortality rate. Those who took supplements at > or = 5 times the
       recommended dietary allowance (RDA) of vitamins B1 and B2 showed a
       significantly decreased rate of progression to death: vitamin B1 (RH =
       0.57, 95% CI = 0.34-0.96) and vitamin B2 (RH = 0.58, 95% CI =
       0.34-0.98). Those taking vitamin B6 supplements at only > or = 2 times
       the RDA showed a similar beneficial effect (RH = 0.59, 95% CI =
       0.37-0.96). CONCLUSIONS: We have found that high intakes of several
       nutrients (vitamins B1, B2, B6, C, and niacin) are associated with
       decreased mortality rates and increase 70th percentile survival times by
       205 days (B1) to 591 days (B6). Much of the protective effect appeared
       to be due to the intake of supplements.
 DE    Acquired Immunodeficiency Syndrome/*DRUG THERAPY/*MORTALITY  Human
       *HIV-1  Niacin/THERAPEUTIC USE  Riboflavin/THERAPEUTIC USE  Survival
       Rate  Thiamine/THERAPEUTIC USE  Trace Elements/*THERAPEUTIC USE  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).