Document 1048
 DOCN  M94A1048
 TI    The effect of hyperbaric oxygenation (HBO) on HIV-associated chronic
       fatigue.
 DT    9412
 AU    Steinhart CR; Montoya I; Kaiser MR; Mercy Hospital, Miami, Florida
       33133.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):220 (abstract no. PB0893). Unique
       Identifier : AIDSLINE ICA10/94371527
 AB    OBJECTIVES: to determine the efficacy of HBO treatment for
       HIV-associated fatigue. METHODS: 4 patients (2 CDC Class B2, 2 Class C3)
       underwent HBO treatments (100% 02 at 2 ATA for 90 min) thrice weekly for
       4 weeks. Karnofsky scores (KS), MOS-HIV Quality of Life questionnaires
       and routine laboratory tests including lymphocyte phenotype were
       obtained. RESULTS: All patients tolerated their HBO treatments with no
       adverse events. HBO was without effect in 1 Class B2 pt during the
       4-week trial, but a significant loss of energy was reported post-HBO.
       The other reported an increased energy level and improvement in quality
       of life and physical and emotional condition. KS improved 20%. For the
       Class C-3 patients, less fatigue occurred in 1 during HBO, but energy
       level and quality of life significantly deteriorated post-treatment. The
       second pt. reported an increase in exercise tolerance and energy level
       and a significant improvement in overall physical and emotional health.
       None of the patients had any significant changes in their laboratory
       test parameters. CONCLUSION: in 3 of 4 patients with mid to late stage
       disease, HBO subjectively improved quality of life and reduced fatigue.
       Interestingly the pt reporting no effect during treatment had a decrease
       in energy level and increased fatigue after it was terminated! Six other
       patients are currently undergoing a 6-week course of HBO treatments. The
       results from the trial will be included in our report.
 DE    Chronic Disease  Fatigue/*THERAPY  Human  *Hyperbaric Oxygenation  HIV
       Infections/*THERAPY  Quality of Life  CLINICAL TRIAL  MEETING ABSTRACT

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