Document 1064
 DOCN  M94A1064
 TI    Potential role of traditional Chinese Kampo medicine (TCM) in treatment
       for HIV infection.
 DT    9412
 AU    Miyamoto K; Inada Y; Lange M; Furukawa T; Fukuoka Univ. and Univ.
       Hospital, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):217 (abstract no. PB0882). Unique
       Identifier : AIDSLINE ICA10/94371511
 AB    OBJECTIVE: In the hope of exploring the possible applications of Kampo
       medicine for HIV infection, we examined HIV infected subjects if they
       had specific conformation or not. Based on our previous findings that
       one of a TCM, Sho-Saiko-To(SST), inhibited the production of factors
       which facilitate the replication of HIV, such as superoxide(SOx) and
       prostaglandin E2, the method to detect more sensitively and simply SOx
       production was further investigated. METHODS: (1) 40 HIV infected
       homosexual subjects (Asymptomatic 30, ARC 4, AIDS 6) were examined to
       diagnose the conformation for application of Kampo medicine according to
       the TCM diagnostic method. (2) SOx production from neutrophils
       stimulated with phorbol myristate acetate (PMA) and opsonized
       zymosan(OpZ) were determined by Flow Cytometry method using 100
       microliters of whole blood. Effect of TCMs on SOx production was
       investigated. RESULTS AND DISCUSSION: (1) 65% of the HIV infected
       subjects showed the conformation of SST or combined prescription with
       SST. Since TCM is clinically effective when the patient has
       corresponding conformation, SST may be widely applicable for HIV
       infection. (2) SOx scavenging effect of TCM was more sensitively
       detected when stimulated with OpZ than with PMA, indicating this
       Micro-assay by Flow Cytometry may be a useful method to evaluate the
       effect of TCM on SOx production.
 DE    Human  HIV Infections/METABOLISM/*THERAPY  *Medicine, Chinese
       Traditional  Neutrophils/METABOLISM  Superoxides/METABOLISM  CLINICAL
       TRIAL  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).