Document 1084
 DOCN  M94A1084
 TI    Participation of HIV positive patients in clinical trials: motivations,
       psychological support and effects.
 DT    9412
 AU    Fauche N; Obadia M; Bicart-See A; Partisani M; Lapeyre M; Beslay C;
       Auvergnat JC; Department of Infectious Diseases, Hopital Purpan,
       Toulouse,; France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):212 (abstract no. PB0860). Unique
       Identifier : AIDSLINE ICA10/94371491
 AB    OBJECTIVE: To evaluate the importance and the particularity in the
       relationship between physician and patient in clinical trials, through
       the analysis of the real motivations in participation (the reasons put
       forward and the cause), and the analysis of the benefits and
       difficulties met along the trial. METHODS: Quantitative study a closed
       questionnaire with 70 items has been distributed to 150 patients from 2
       french clinical centers (Toulouse and Strasbourg). We just included
       patients enrolled in multicentric trials (Concorde, Delta...). This
       questionnaire examinates: the relationship with the regular physician
       who proposed first the participation in the trial, the relationship with
       the trial physician, the motivations and decision making, the
       expectations and crises, the benefits and constraints (at material,
       psychological and social levels). Qualitative study: 12 interviews were
       realized. From the analysis of contents and a psychoanalytical reading
       and comment, we derived the patients' particular subjective positions
       towards the trial. RESULTS: The real motivation (the cause) results from
       the nature of the relationship with the regular physician who proposed
       first the participation in the trial. The other reasons put forward by
       the patient (help to find a treatment, benefit of a new treatment,
       altruism ...) come after the decision. The motives to follow up the
       clinical trial are also due to the quality of the relationship with the
       trial physician. Particularities of this relationship will be detailed
       in the poster. CONCLUSIONS: Clinical trials usually represent a seat of
       research and high technology. However, the relationship between
       physician and patient in HIV clinical trial is not only a functional,
       technical or professional one. It summons up the patients and
       physicians' subjective dimension. The quality of this relation
       conditions the success of the trial.
 DE    *Clinical Trials  Human  HIV Seropositivity/*PSYCHOLOGY  Motivation
       *Patient Participation  Questionnaires  MEETING ABSTRACT

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