Document 1106
 DOCN  M94A1106
 TI    Acetaminophen (A) metabolism in HIV infection.
 DT    9412
 AU    Gonzalez M; Esteban A; Mora A; Priego M; Boix V; Portilla J; Perez-Mateo
       M; Universitary Hospital of Alicante, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):208 (abstract no. PB0844). Unique
       Identifier : AIDSLINE ICA10/94371469
 AB    OBJECTIVE. To investigate possible differences in A metabolism between
       HIV infected patients and healthy controls. To search the importance of
       clinical staging in A metabolism. PATIENTS AND METHODS. Nineteen aids
       inpatients, 9 asymptomatic HIV(+) antiretroviral naive patients with CD4
       cell counts > 400/mm3 and 32 healthy volunteers have been studied. After
       a single 1 g dose po, 24-hour urine was collected. The total amounts of
       unconjugated A and main A metabolites were measured by HPLC. Results are
       expressed in % of total A recovered. TABULAR DATA, SEE ABSTRACT VOLUME.
       Although half aids patients were treated with AZT we found no
       differences between them and those not receiving AZT. CONCLUSIONS. 1. A
       metabolism is severely disturbed in aids but not in asymptomatic HIV(+)
       patients. 2. Toxic oxidative metabolites production is increased in aids
       and unrelated with AZT. 3. These facts could explain the susceptibility
       to A-induced hepatotoxicity in aids.
 DE    Acetaminophen/*PHARMACOKINETICS  Acquired Immunodeficiency
       Syndrome/METABOLISM  Chromatography, High Pressure Liquid  Human  HIV
       Infections/*METABOLISM  HIV Seropositivity/METABOLISM  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).