Document 1130
 DOCN  M94A1130
 TI    ComPACT 1: a randomized, controlled trial of immediate vs. deferred
       antiretroviral therapy in asymptomatic HIV infected individuals.
 DT    9412
 AU    Mitchell T; Abrams D; Smith RP; Meier P; Peto R; University of
       California, San Francisco.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):202 (abstract no. PB0821). Unique
       Identifier : AIDSLINE ICA10/94371445
 AB    It is unclear from the currently available evidence whether a policy of
       immediate or deferred intervention with antiretroviral therapy would
       produce the best chances of increased survival in asymptomatic HIV
       infection. In order to reliably assess which policy is best, a pilot
       study for a large, simple trial is under way. Primary care providers in
       New York, San Francisco, Los Angeles and Washington DC are able to
       randomize their patients to a policy of immediate or Deferred
       antiretroviral therapy through a toll free call. Annual follow up
       includes the participant's most recent CD4 cell count, whether they are
       taking antiretroviral therapy, and the date when the person was last
       known to be alive. Updated information on the rate of enrollment, the
       demographics and compliance of enrolled patients will be presented. Of
       the patients for whom follow up data are available, 50% have CD4 cell
       counts above 500 (range 70-1014). Ages range from 21-60. 45% are people
       of color, 6% are women. If the pilot study is successful, a large scale
       randomization is planned, within which at least 10,000 asymptomatic HIV
       infected people would be invited to participate.
 DE    Adult  Antiviral Agents/*ADMINISTRATION & DOSAGE  Female  Human  HIV
       Infections/*DRUG THERAPY/IMMUNOLOGY  Leukocyte Count  Male  Middle Age
       Pilot Projects  T4 Lymphocytes  CLINICAL TRIAL  MEETING ABSTRACT
       RANDOMIZED CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).