Document 1145
 DOCN  M94A1145
 TI    Clinical and laboratorial evaluation of the endocrine pancreas in AIDS.
 DT    9412
 AU    Pires ML; Silva MA; Lima MB; Carrera JA; Vangueloti AM; Ribeiro JE;
       Faulhaber MH; University of Rio de Janeiro, Brasil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):199 (abstract no. PB0809). Unique
       Identifier : AIDSLINE ICA10/94371430
 AB    OBJECTIVE: Evaluate the clinical and laboratorial occorrence of
       hypoglycemia, hyperglycemia, hypoinsulinism and hyperinsulinism in
       carries of the HIV, in the different levels of the infection. METHODS:
       36 patients (pt), amay 20-50 years of age, without any prior history of
       Diabetes Mellitus, were classified in 4 groups (G): 10 pt with
       anti-HIV(-) tests (GI) and 26 with anti-HIV(+) tests, amay these pt, 10
       pt non symptomatics (GII), 6 pt with ARC(GIII) and 10 pt with AIDS(GIV).
       The evaluatin was done by the oral glucose tolerance test (OGTT) with
       simultaneous dosage of insulin. The statistical methods used were ANOVA
       and Newman-Keuls. RESULTS: One case of hypoglycemia was found in GIII
       (16.7%) and 4 cases in GIV (40%). Comparing the medium of the results of
       the lasting plasma glucose ans insulinism from the area of the curve of
       the glycemia and the total amount of insulinism there were no
       significant statistical difference among these groups, however, it was
       verified significant statistical difference related to the area under
       insulin curve (p < 0.0005). CONCLUSIONS: a) The clinical and
       laboratorial hypoglycemia observed in the GIV, was not statistically
       significant when compared to the other group; b) There were not found
       any case of hyperglycemia; c) Hiperliberation of basal insulin in the
       group II seems to be related hypermetabolism on this phase; d) Minor
       value of the area under the insulin curve as well as the total amount of
       the insulinim in the group IV was significant statiscally and its
       multifatorial cause.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*METABOLISM  Adult
       AIDS-Related Complex/METABOLISM  Glucose Tolerance Test  Human
       Hyperglycemia/COMPLICATIONS/DIAGNOSIS
       Hyperinsulinism/COMPLICATIONS/DIAGNOSIS
       Hypoglycemia/COMPLICATIONS/DIAGNOSIS  HIV Seropositivity/METABOLISM
       Insulin/METABOLISM  Islets of Langerhans/*METABOLISM  Middle Age
       MEETING ABSTRACT

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